Joe Allen has been ruled out of Wales' Euro 2016 qualifier against Israel with a hamstring injury.
The Liverpool midfielder was suspended for the 3 September trip to Cyprus but will also miss the game with Israel three days later in Cardiff.
Defender Adam Matthews is also out after being injured in Sunderland's 6-3 League Cup win against Exeter.
Real Madrid forward Gareth Bale is included having declared his fitness after a toe injury worry.
James Collins, Ben Davies and David Edwards return after missing June's 1-0 win over Belgium through injury.
But Nottingham Forest midfielder David Vaughan has been ruled out, while fellow midfielder Joe Ledley has not being playing regularly this season for Crystal Palace.
Allen's Liverpool team-mate and fellow midfielder Jordan Williams, who is currently on loan at League One side Swindon Town, is included and could win his first cap.
Wayne Hennessey's inclusion should see the Crystal Palace goalkeeper win his 50th international cap against Cyprus in Nicosia.
Wales have a three-point lead at the top of Euro 2016 qualifying Group B with four games remaining.
Wins in both games against Cyprus at the GSP Stadium in Nicosia and Israel at Cardiff City Stadium could be enough to seal Wales' place at a major finals for the first time since 1958.
The top two sides from each group qualify automatically for the Euro 2016 finals in France, with Wales holding a five-point lead over third-placed Israel going into September's games.
Israel will be without star striker Omer Damari for their game on 6 September, as the 26-year-old Red Bull Salzburg player has been ruled out with a broken foot.
Damari has five goals in this campaign, making him joint top scorer in the section with Wales' Bale and Bosnia-Hercegovina striker Edin Dzeko.
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